Publikationen Prof. Dr. B. Jastorff, Stand: 23.04.2002

Synthese

1 Jastorff, B., and Hettler, H. (1969)
Phosphorylation of 5'amino 5'-desoxynucleosides.
Tetrahedron Letters 30, 2543 - 2544

2 Jastorff, B., und Hettler, H. (1969)
Nucleosidanaloge von 5'Amino 5'-desoxynucleosiden.
Chem. Ber. 102, 4119 - 4127

3 Murayama, A., Jastorff B., and Hettler, H. (1970)
Synthesis of 5'amino analogs of adenosine (3',5')-cyclophosphates.
Angew. Chem. 82, 666
Angew. Chem. Int. Ed. Engl. 9, 640 - 641

4 Murayama, A., Jastorff, B., Cramer, F., and Hettler, H. (1971)
5'-Amino analogs of adenosine 3',5'-cyclic monophosphate.
J. Org. Chem. 36, 3029 - 3033

5 Jastorff, B., und Freist, W. (1972)
Neue Analoge des Adenosin-3',5'-cyclophosphats.
Angew. Chem. 84, 711 - 712 - Angew. Chem. Int. Ed. Engl. 11, 713

6 Freist, W., Schattka, K., Cramer, F., und Jastorff, B. (1972)
Neue Darstellungsmethoden von Nucleotidanalogen der 5'-Amino-5'-desoxynucleotide.
Chem. Ber. 105, 991 - 999

7 Jastorff, B., und Krebs, T. (1972)
Synthese des Adenosin-3',5'cyclophosphats mit Stickstoff und Schwefelatomen im Ring.
Chem. Ber. 105, 3192 - 3202

8 Schattka, K., und Jastorff, B. (1972)
5'Amino-5'-desoxyguanosin und seine 5'-N-substituierten Derivate.
Chem. Ber. 105, 3824 - 3832

9 Murayama, A., Jastorff, B., Hettler, H., und Cramer, F. (1973)
Die Stereoselektivität bei der Synthese von 5'-N-substituierten 5'-Amido-Analogen des Adenosin-3',5'cyclophosphat p-nitrophenylesters.
Chem. Ber. 106, 3127 - 3131

13 Schattka, K., und Jastorff, B. (1974)
Synthetische Untersuchung der Phosphorylierungsbedingungen für 5'Amino-5'-Desoxyguanosin-Verbindungen.
Chem. Ber. 107, 3043 - 3052

14 Jastorff, B., and Freist, W. (1974)
Synthesis and biological activities of cyclic AMP analogs modified in the 1,2 and 2'-positions.
Bioorg. Chem. 3, 103 - 113

15 Morr, M., Kula, M.-R., Roesler, G., und Jastorff, B. (1974)
Synthese des 3'-Amido-3'-desoxyadenosin-3',5'-cyclophosphats.
Angew. Chem. 86, 308

52 Schiebel, H.-M., Schulze, P., Stohrer, W.-D., Leibfritz, D., Jastorff, B., and Maurer, K.H. (1985)
Fast atom bombaardement (FAB) mass spectrometry of nucleoside cyclophosphates and structurally related compounds. FAB-induced reactions before desorption.
Biomed. Mass Spectrometry 12, 170 - 180

76 Genieser, H.-G., Dostmann, W., Bottin, U., Butt, E., and Jastorff, B. (1988)
Synthesis of nucleoside-3',5'-cyclic phosphothioates by cyclothiophosphorylation of unprotected nucleosides.
Tetrahedron Letters 29, 2803 - 2804

78 Schultz, C., Metschies, T., and Jastorff, B. (1988)
Synthesis of thiophosphate analogues of DL-myo-inositol 1,2-cyclic phosphate.
Tetrahedron Letters 29, 3919 - 3920

79 Metschies, T., Schultz, C., and Jastorff, B. (1988)
Synthesis of D,L-myo-inositol-1-phosphate and its thiophosphate analogue.
Tetrahedron Letters 29, 3921 - 3922

81 Genieser, H.-G., Butt, E., Bottin, U., Dostmann, W., and Jastorff, B. (1989)
Synthesis of the 3',5'-cyclic phosphates from unprotected nucleosides.
Synthesis 1, 53 - 54

84 Genieser, H.-G., Dostmann, W., and Jastorff, B. (1989)
Verfahren zur Herstellung von Nucleosid-3'5'-cyclothiophosphaten als Agonisten oder Antagonisten.
Offenlegungsschrift DE 3802865 A1

85 Genieser, H.-G., Dostmann, W., and Jastorff, B. (1989)
Verfahren zur Herstellung von Nucleosid-3'5-cyclophosphaten als Agonisten.
Offenlegungsschrift DE 3802866 A1

88 Schultz, C., Metschies, T., Gerlach, B., Stadler, C., and Jastorff, B. (1990)
Regioselective synthesis of inositol phosphate diesters via a cyclic phosphate triester.
Approach. Synlett. 3, 163 - 166

106 Genieser, H.-G., Winkler, E., Butt, E., Zorn, M., Schulz, S., Iwitzki, F., Störmann, R., and Jastorff, B. (1992)
Derivatives of 1-ß-D-ribofuranosylbenzimidazole3',5'-phosphate that mimic the actions of adenosine 3',5'-phosphate (cAMP) and Guanosine 3',5'-phosphate (cGMP).
Carbohydrate Research 234, 217 - 235

128 Roemer, S., Stadler, C., Rudolf, M.T., Jastorff, B., and Schultz, C. (1996)
Membrane-permeant analogues of putative second messenger myo-inositol 3,4,5,6-tetrakisphosphate.
J. Chem. Soc., Perkin trans. 1, 1683 - 1694

130 Hoffman, C., Genieser, H.G., Veron, M., and Jastorff, B. (1996)
Novel synthesis of nucleoside 5'-polyphosphates.
Bioorg. Med. Chem. Lett., 21, 2571 - 2574

134 Kruppa, J., Keely, S., Schwede, F., Schultz, C., Barrett, K.E., and Jastorff, B. (1997)
Bioactivatable derivatives of 8-substituted cAMP-analogues.
Bioorg. Med. Chem.Lett. 7, 945 - 948

146 Schwede, F., Brustugun, O.T., Zorn-Kruppa, M., Døskeland, S.O., and Jastorff, B. (2000)
Membrane-Permeant, Bioactivatable Analogues of cGMP as Inducers of Cell Death in IPC-81 Leukemia Cells.
Bioorg. Med. Chem. Lett. 10, 571 - 573

Chromatographische Arbeiten

32 Genieser, H.-G., Gabel, D., and Jastorff, B. (1981)
Quantitative ether cleavage of ligands in hydrophobic agaroses: precise determination of the degree of substitution.
J. Chromat. 215, 235 - 242

36 Genieser, H.-G., Gabel, D., and Jastorff, B. (1982)
Determination of ligand contents on octadecyl modified silicas.
J. Chromat. 244, 368 - 372

42 Genieser, H.-G., Gabel, D., and Jastorff, B. (1983)
Characterization of silica bonded stationary phases.
J. Chromat. 269, 127 - 152

43 Genieser, H.-G., Gabel, D., and Jastorff, B. (1983)
Gas chromatographic adsorption effect arising from boron trihalides.
J. High Resol. Chromat. Commun. 6, 515

56 Braumann, T., and Jastorff, B. (1985)
Physico-chemical characterization of cyclic nucleotides by reversed-phase high performance liquid chromatography I. cation binding in the mobile phase.
J. Chromat. 329, 321 - 330

57 Braumann, T., and Jastorff, B. (1985)
Physico-chemical characterization of cyclic nucleotides by reversed phase high performance liquid chromatography II. Quantitative determination of hydrophobicity.
J. Chromatogr. 350, 105 - 118

60 Lüllmann, C., Genieser, H.-G., and Jastorff, B. (1985)
Structural investigations on reversed-phase silicas determination of ligand functionality.
J. Chromat. 323, 273 - 280

61 Lüllmann, C., Genieser, H.-G., and Jastorff, B. (1986)
Structural investigations on reversed phased silicas. II evidence for endcapping trimethylsilyl groups.
J. Chromat. 354, 434 - 437

74 Braumann, T., Genieser, H.-G., Lüllmann, C., and Jastorff, B. (1987)
Determination of hydrophobic parameters of reversed phase high performance liquid chromatography. Effects of stationary phase.
Chromatographia 24, 777 - 782

127 Turowski, M., Kaliszan, R., Lüllmann, C., Genieser, H.G., Jastorff, B. (1996)
New stationary phases for the high-performance liquid chromatographic separation of nucleosides and cyclic nucleotides, synthesis and chemometric analysis of retention data.
J. Chromatogr. A, 728, 201 - 211

129 Burmester, A., and Jastorff, B. (1996)
Enantioseparation in the synthesis of myo-inositol phosphates by high-performance liquid chromatography using a ß-cyclodextrin-bonded column.
J.Chromatogr. A, 749, 25 - 32

132 Krass, J., Jastorff, B., and Genieser, H.-G. (1997)
Determination of lipophilicity by gradient elution high-perfomance liquid chromatography.
Anal.Chem. 69, 3575-2581

133 Meissner, T., Eisenbeiss, F., Feige, K., und Jastorff, B. (1997)
Isotachophoretische Spurenanalyse in ionischen Überschußkomponenten.
GIT Lab. 41, 728 - 733

135 Meissner, T, Eisenbeiss, F., and Jastorff, B. (1998)
Determination of anionic trace impurities in acetic acid by two-dimensional capillary isotachophoresis.
Fresenius Journal of Anal, 361, 459 - 464

136 Markuszewski, M., Krass, J.D., Hippe, T., Jastorff, B., and Kaliszan, R. (1998)
Separation of nitroaromatics and their transformation products in soil around ammunition plants: new high performance liquid chromatographic charge transfer stationary phases.
Chemosphere, Vol. 37, 3, 559 - 575

138 Kaliszan, R., Markuzewski, M., Jastorff, B., Krass, J.D., Hippe, T. (1998)
New HPLC stationary phases for separation of nitroaromatics in soil around former ammunition plants. Chemometric classification of stationary phases and pollutants.
Chromatography, Vol 19, No. 4

139 Meissner Th., Eisenbeiss F., Jastorff B. (1998)
Determination of anionic trace impurities in glycerol by capillary isotachophoresis with enlarged sample load.
J. Chromatogr. A 810, 201 - 208

141 Meissner, T, Eisenbeiss, F., and Jastorff, B. (1998)
Capillary zone electrophoresis and ion chromatography in the low ug/l range applied to the determination of anions in hydogen peroxide.
J. Chromatogr. A , 829, 351 - 357

145 Meissner, T, Eisenbeiss, F., and Jastorff, B. (1999)
New leading electrolyte for the direct determination of chloride and other anions in analytical isotachophoresis.
J. Chromatogr. A , 838, 81 - 88

155 Rittner, M., Ingendoh, A., Sander, P. und Jastorff, B. (2001)
HPLC/ MS-Bibliothek: Projekt einer Kooperation.
GIT Labor-Fachzeitschrift 11, 1208 - 1212

Struktur-Wirkungsbeziehungen von Cyclonucleotidanalogen in
Dictyostelium discoideum (ein interdisziplinäres Projekt)

10 Konijn, T.M., and Jastorff, B. (1973)
The chemotactic effect of 5'-amido-analogues of adenosine cyclic 3',5'-monophosphate in the cellular slime moulds.
Biochim. Biophys. Acta 304, 774 - 780

11 Malchow, D., Fuchila, J., and Jastorff, B. (1973)
Correlation of substrate specifity of cAMP-phosphodiesterase in Dictyostelium discoideum with chemotactic activity of cAMP analogues.
FEBS Lett. 34, 5 - 9

21 Jastorff, B., Konijn, T.M., Mato, S., Hoppe, J., and Wagner, K.G. (1978)
Comparison of the molecular interactions between cAMP and its receptor protein in Dictyostelium discoideum and protein kinase type I.
Hoppe-Seyler's Z. Physiol. Chem. 359, 281

23 Mato, J., Jastorff, B., Morr, M., and Konijn, T.M. (1978)
A model for cAMP chemoreceptor interaction in Dictyostelium discoideum.
Biochem. Biophys. Acta 544, 309 - 314

35 Van Haastert, P.J.M., Jastorff, B., Pinas, J.E., and Konijn, T.M. (1982)
Analogs of adenosine 3',5'-monophosphate as chemoattractants and inhibitors in Dictyostelium discoideum.
J. Bact. 149, 99 - 105

44 Van Haastert, P.J.M., Dijckgraaf, P.A.M., Konijn, T.M., Abbad, E.G., Petridis, B., and Jastorff, B. (1983)
Substrate specifity of cyclic nucleotide phosphodiesterase from beef heart and from Dictyostelium discoideum.
Eur. J. Biochem. 131, 659 - 666

64 Brandt, Ch., Jastorff, B., and Hildebrandt, A. (1986)
Sporulation delay by stabile cAMP analogues in the slime mould physarum polycephalum.
Rou'x Arch. Dev. Biol. 195, 276 - 280

67 Theibert, A., Palmisano, M., Jastorff, B., and Devreotes, P. (1986)
The specifity of the cAMP-receptor mediating activation of adenylate cyclase in Dictyostelium discoideum.
Developmental Biology 114, 529 - 533

96 Ments-Cohen, M., Genieser, H.-G., Jastorff, B., van Haastert, P.J.M., and Schaap, P. (1991)
Kinetics and nucleotide specifity of a surface cAMP binding site in Dictyostelium discoideum, which is not down-regulated by cAMP.
Microbiol. Lett. 82, 9 - 14

103 Johnson, R.L., van Haastert, P.J.M., Kimmel, A.R., Saxe III, C.L., and Jastorff, B. (1992)
The cyclic nucleotide specificity of three cAMP receptors in Dictyostelium.
J. Biol. Chem. 267, 4600 - 4607

108 Schaap, P., van Ments-Cohen, M., Soede, Ron D.M, Brandt, R., Firtel, R.A., Dostmann, W., Genieser, H.-G., Jastorff, B., and van Haastert, P.J.M. (1993)
Cell-permeable non-hydrolyzable cAMP derivatives as tools for analysis of signaling pathways controlling gene regulation in Dictyostelium.
J. Biol. Chem. 268, No. 9, 6323 - 6331

Struktur-Wirkungsbeziehungen in cAMP-abhängigen Proteinen
(ein interdisziplinäres Projekt)
cAMP-abhängige Proteinkinasen

12 Jastorff, B., and Baer, H.P. (1973)
Effects of 5'-amido analogues of adenosine 3',5'-monophosphate and adenosine 3',5'-monophosphothioate on protein kinase, binding protein and phosphodiesterases.
Eur. J. Biochem. 37, 497 - 504

16 Hoppe, J., Jastorff, B., Panitz, N., Rieke, E., and Wagner, K.G. (1974)
Substituted cAMP: conformation and interaction with specific enzymes.
Hoppe-Seyler's Z. Physiol. Chem. 355, 1209

17 Panitz, N., Rieke E., Morr, M., Wagner, K.G., Roesler, G., and Jastorff, B. (1975)
The 3'- and 5'-amido analogues of cyclic AMP: interaction with cAMP-specific proteins.
Eur. J. Biochem. 55, 415 - 422

18 Simonson, L.P., Baer, H.P., Jastorff, B., and Hitkari, R. (1975)
An extended scatchard analysis for competitively bound ligands and its application to cyclic adenosine-3',5'-monophosphate and cyclic 5'-amido-5'-deoxyadenosine-3',5'-monophosphate binding to beef skeletal muscle protein.
Biochem. Biophys. Acta 397, 114 - 124

20 Wagner, K.G., Hoppe, J., Rieke, E., and Jastorff, B. (1978)
Mechanism of activation of protein kinase I.
Hoppe-Seyler's Z. Physiol. Chem. 359, 333 - 334

24 Jastorff, B., Hoppe, J., and Wagner, K.G. (1978)
Mapping the cyclic phosphate binding site of protein kinase.
Adv. Cyclic Nucleotides Res. 9, 760

25 Jastorff, B. (1978)
5'-Amino-5'-deoxyadenosine-3'-phosphates mimicking the biological activity of of cAMP.
Adv. Cyclic Nucleotides Res. 9, 770

27 Jastorff, B., Hoppe, J., and Morr, M. (1979)
A model for the chemical interactions of adenosine 3',5'-monophosphate with the R subunit of protein kinase type I. Refinement of the cyclic phosphate binding moiety of protein kinase type I.
Eur. J. Biochem. 101, 555 - 561

33 de Wit, R.J.W., Hoppe, J., Stec, W.J., Baraniak, J., and Jastorff, B. (1982)
Interaction of cAMP derivatives with the stable cAMP binding site in the cAMP-dependent protein kinase type I.
Eur. J. Biochem. 122, 95 - 99

48 Van Haastert, P.J.M., Van Driel, R., Jastorff, B., Baraniak, J., Stec, W.J., and de Wit, R.J.W. (1984)
Competitive cAMP antagonists for cAMP-receptor proteins.
J. Biol. Chem. 259, 10020 - 10040

49 de Wit, R.J.W., Hekstra, D., Jastorff, B., Stec, W.J., Baraniak, J., Van Driel, R., and Van Haastert, P.J.M. (1984)
Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases.
Eur. J. Biochem. 142, 255 - 260

92 Dostmann, W., Taylor, Susan S., Genieser, H.-G., Jastorff, B., Døskeland, S.O., and Oegreid, D. (1990)
Analogs of adenosine cyclic-3',5'-phosphorothioates: Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinase I and II.
J. Biol. Chem. 265, 10484 - 10491

119 Zorn, M., Fladmark, K.E., Oegreid, D., Jastorff, B., Døskeland, S.O., and Dostmann, W.R.G. (1995)
Ala335 is essential for high-affinity cAMP-binding of both sites A and B of cAMP-dependent protein kinase type I.
FEBS Lett. 362, 291 - 294

148 Schmitt, H., Altenburger, R., Schüürmann, G., and Jastorff, B. (2000)
Quantitative Structure-Activity Analysis of the Algae Toxicity of Nitroaromatic Compounds.
Chemical Research in toxicology Vol. 13, No. 6, 441 - 450

cGMP-abhängige Proteinkinasen

58 Hofmann, F., Gensheimer, H.P., Landgraf, W., Hullin, R., and Jastorff, B. (1985)
Diastereomers of adenosine 3',5'-monothionophosphate (cAMPS) antagonize activation of cGMP-dependent protein kinase.
Eur. J. Biochem 150, 85 - 88

68 Corbin, J.D., Oegreid, D., Miller, J.P., Suva, R.H., Jastorff, B., and Døskeland, S.O. (1986)
Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase.
J. Biol. Chem. 261, 1208 - 1214

90 Butt, E., van Bemmelen, M., Fischer, L., and Jastorff, B. (1990)
Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3',5',-monophosphorothioates.
FEBS Lett. 263, 47 - 50

101 Butt, E., Nolte, C., Schulz, S., Beltman, J., Beavo, J.A., Jastorff,B., and Walter,U. (1992)
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-pCPT-cGMP.
Biochem. Pharmacol. 43, 2591 - 2600

102 Sekhar, K.R., Hatchett, J., Shabb, J.B., Wolfe, L., Francis, S.H., Wells, J.M., Jastorff, B., Butt. E., Chakinala, M.M., and Corbin, J.D. (1992)
Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type Ia compared with type Iß, cGMP-dependent protein kinase.
Mol. Pharmacol. 42, 103 - 108

Rp-cAMPS/ Sp-cAMPS und ihre Analoga: cAMP-Antagonisten / -Agonisten
[Proteinkinase A-Inhibitor / -Aktivator]
(interdisziplinäre Studien)

40 Rothermel, J.D., Stec, W.J., Baraniak, J., Jastorff, B., Parker, L.H., and Botelho, L. (1983)
Inhibition of glycogenolysis in isolated rat hepatocytes by the Rp diastereomer of adenosine cyclic 3',5'-phosphorothioate.
J. Biol. Chem. 258, 12125 - 12128

46 Rothermel, J.D., Jastorff, B., Parker L.H and Botelho, L. (1984)
Inhibition of glucagon-induced glycogenolysis in isolated rat hepatocytes by the Rp-diastereomer of adenosine cyclic 3',5'-phosphorothioate.
J. Biol. Chem. 259, 8151 - 8155

47 Scholübbers, H.-G., Van Knippenberg, P.H., Baraniak, J., Stec, W.J., Morr, M., and Jastorff, B. (1984)
Investigations on stimulation of lac transcription in vivo in Escherichia coli by cAMP analogues.
Eur. J. Biochem. 138, 101 - 109

54 Richter-Landsberg, C., and Jastorff, B. (1985)
In vitro phosphorylation in microtubule-associated protein 2: differential effect of cyclic AMP analogues.
J. Neurochem. 45, 1218 - 1222

62 Erneux, C., Van Sande, J., Jastorff, B., and Dumont, J.E. (1986)
Modulation of cyclic AMP action in the dog thyroid by its agonist and antagonist Sp- and Rp-adenosine 3',5'-monophosphorothioate.
Biochem. J. 234, 193 - 197

66 Richter-Landsberg, C., and Jastorff, B. (1986)
The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC 12 cells.
J. Cell Biol. 102, 821 - 829

70 Schmid, E., Schmid, W., Jantzen, M., Mayer, D., Jastorff, B., and Schütz, G. (1987)
Transcription activation of the tyrosine aminotransferase gene by glucocorticoids and cAMP in primary hepatocytes.
Eur. J. Biochem. 165, 499 - 506

71 Van Haastert, P.J.M., Kesbeke, F., Konijn, T.M., Baraniak, J., Stec, W.J., and Jastorff, B. (1987)
(Rp)-cAMPS, an antagonist of cAMP, in Dictyostelium discoideum.
In Biophosphates and their analogues - synthesis, structure, metabolism and activity.
Eds.: K.S. Bruzik, W.J. Stec, 469 - 483

72 Hescheler, J., Tang, M., Jastorff, B., and Trautwein, W. (1987)
On the mechanism of histamine-induced enhancement of the Ca2+ current.
Eur. J. Chem., Pflügers Archiv 410, 23 - 29

73 Richter-Landsberg, C., and Jastorff, B. (1987)
Effect of nerve growth factor and cAMP analogues on neuronal differentiation in PC 12 cells: studies with an inhibitor of cAMP dependent protein kinases. in Glial-neuronal communication in development and regulation.
Eds. H.H. Althaus, Springer-Verlag, 333 - 354

75 Parker-Botelho, L.H., Rothermel, J.D., Coombs, R.V., and Jastorff, B. (1988)
cAMP analog antagonists of cAMP action.
Methods in Enzymology 159, 159 - 172

80 Büchler, W., Walter, U., Jastorff, B., and Lohmann, S.M. (1988)
Catalytic subunit of cAMP dependent protein kinase is essential for cAMP-mediated mammalian gene expression.
FEBS Lett. 228, 27 - 32

86 Maronde, E., Günster, H.K., Jastorff, B., and Richter-Landsberg, C. (1989)
Influence of cyclic nucleotide derivatives of growth and differentiation of C-6 rat glioma cells. Dynamics and Plasticity in Neuronal Systems.
(Eds. Elsner, N., and Singer, W.) 224, Georg Thieme-Verlag, Stuttgart

91 Techel, D., Gebauer, G. Kohler, W., Braumann, T., Jastorff, B., and Rensing, L.(1990)
On the role of Ca2+-calmodulin-dependent and cAMP-dependent protein phosphorylation in the circadian rhythm of Neurospora crassa.
J. Comp. Physiol. B. 159, 695 - 706

93 Adashi, E.Y., Resnick, C.E., and Jastorff, B. (1990)
Blockade of granulosa cell differentiation by an antagonistic analog of adenosine 3',5'-cyclic phosphate (cAMP): central but non-exclusive intermediary role of cAMP in follicle-stimulating hormone action.
Mol. Cell. Endocrinol. 72: 1-11

99 Sandberg, M., Butt, E., Nolte, C., Fischer, L., Halbrügge, M., Beltmann, J., Jahnsen,T., Genieser,H.-G., Jastorff,B., and Walter,U. (1991)
Characterization of Sp-5,6-dichloro-1-ß-D-ribofuranosyl-benzimidazole-3',5'-monophospohorothioate (Sp-5,6-DCl-cBiMPS) as a potent and specific activator of cyclic-AMP-dependent protein kinase in cell extracts and intact cells.
Biochem. J. 279, 521 - 527

107 Yokozaki, H., Tortora, G., Pepe, S., Maronde, E., Genieser, H.-G., Jastorff, B., and Cho-Chung, Y.-S. (1992)
Unhydrolysable analogs of adenosine-3',5'-monophosphat demonstrating growth inhibition and differentiation in human cancer cells.
Cancer Res. 52, 2504 - 2508

115 Oegreid, D., Dostmann, W., Genieser, H.-G., Niemann, P., Døskeland, S.O., and Jastorff, B. (1994)
(Rp)- and (Sp)-8-Piperidino-adenosine 3',5'-(cyclic)thiophosphates discriminate completely between site A and B of the regulatory subunits of cAMP-dependent protein kinase type I and II.
Eur. J. Biochem. 221, 1089 - 1094

118 Schultz, C., Vajanaphanich, M., Genieser, H.-G., Jastorff, B., Barrett, K.E., and Tsien, R.Y. (1994)
Membrane-permanent derivatives of cyclic AMP optimized for high potency, prolonged activity or rapid reversibility.
Mol. Pharmacol. 46, 702 - 708

121 Gjertsen, B.T., Mellgren, G., Otten, A., Maronde, E., Genieser, H.-G., Jastorff, B., Vintermyr, O.K., McKnight, G.S., and Døskeland,S.O. (1995)
Novel Rp-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1ß action.
J. Biol. Chem. 270, 20599 - 20607

122 Ojeda, F., Folch, H., Guarda, M.I., Jastorff, B., and Diehl, H.A. (1995)
Induction of apoptosis in thymocytes: new evidence for an interaction of PKC and PKA pathways.
Biol. Chem. Hoppe-Seyler 376, 389 - 393

124 Muresan, S., Bologa, C., Mracec, M., Chiriac, A., Jastorff, B., Simon, Z., and Náray-Szabó, G. (1995)
Comparative QSAR study with electronic and steric parameters for cAMP derivatives with large substituents in positions 2, 6 and 8.
J. Mol. Struct. 342, 161 - 171

149 Schwede, F., Christensen, A., Liauw, S., Hippe, T., Kopperud, R., Jastorff, B., and Døskeland, S.O. (2000)
8-Substituted cAMP Analogues Reveal Marked Differences in Adaptability, Hydrogen Bonding, and Charge Accommodation between Homologous Binding Sites (AI/AII and BI/BII) in cAMP Kinase I and II.
Biochemistry Vol. 39, No. 30, 8803-8812

Cyclische Phosphodiesterasen

Projekte zum Metabolismus von cAMP-Analogen (interdisziplinäre Studien)

45 Coulson, R., Baraniak, J., Stec, W.J., and Jastorff, B. (1983)
Transport and metabolism of N6- and C8-substituted analogs of adenosine 3',5'-cyclic monophosphate and adenosine 3',5'-cyclic phosphorothioate by the isolated perfused rat kidney.
Life Science 32, 1489 - 1498

65 Braumann, T., Jastorff, B., and Richter-Landsberg, C. (1986)
Fate of cyclic nucleotides in PC 12 cell cultures: uptake, metabolism, and effect of metabolites on nerve growth factor-induced neurite outgrowth.
J. Neurochem. 47, 912 - 919

Struktur-Wirkungsbeziehungen bei Analogen von Signalmolekülen
(ein interdisziplinärer Denkansatz)

19 Jastorff, B. (1976)
Cyclic nucleotide analogues Eucaryotic cell function and growth
Ed. Dumont, J.E., Brown, B.L., and Marshall, N.J. 379 - 390, Plenum Press.

22 Roesler, G., and Jastorff, B. (1978)
3'-Modified nucleotides: substrate recognition by phosphohydrolases.
Bioorg. Chem. 7, 35 - 45

26 Jastorff, B., Hoppe, J., Mato, J., and Konijn, T.M. (1978)
Comparison of the chemical interactions of cAMP at its binding sites of protein kinase type I from rabbit muscle and the cellular slime mould.
Nucleic Acid Res. Special Publ. 4, 237 - 241

28 Jastorff, B., Hoppe, J., Mato, J., and Konijn. T.M. (1979)
Ligand analogs - a tool for the elucidation of protein ligand interactions model system: cAMP.
Molecular Mech. of Biological Recognition, M Balaban Ed, 107-117 Elsevier/North Holland, Biomedical Press, Amsterdam.

29 Jastorff, B. (1979)
Systematic variations on the structure of adenosine-3',5'-cyclic phosphate. A rational approach to protein ligand interactions. Cyclic Nucleotides and Therapeutic Perspect.
G. Cehovic and G.A.Robinson Ed., 85 - 95, Pergamon Press, Oxford

30 Jastorff, B., Abbad, E.G., Petridis, G., Tegge, W., de Wit, R. , Erneux, C., Stec,W.J., and Morr, M. (1981)
Systematic use of cyclic nucleotide analogues - mapping of essential interactions between nucleotides and proteins.
Nucleic Acids Research, Symp. Ser. 9, 219 - 223

34 Jastorff, B. (1982)
The effects of cyclic nucleotide derivatives on cell metabolism. Cell regulation by intracellular signal molecules.
J.E. Dumont, St. Swillens, ed., 195 - 207, Plenum Press, New York, London

37 Jastorff, B. (1982)
How does chemical binding of small signal molecules to receptor determine complex biological processes?
Ed: M.R. Dohmen, Zoological Laboratory, University of Utrecht.

89 Schultz, C., Gebauer, G. Metschies, T., Rensing, L., and Jastorff,B. (1990)
Cis-cis-cyclohexane 1,3,5-triol polyphosphates release calcium from Neurospora crassa via an unspecific INS 1,4,5-P3-receptor.
Biochem. and Biophys. Research Communications 166, 1319 - 1327

95 Van Lookeren-Campagne, M.M., Villalba Diaz, F., Jastorff, B., and Kessin, R.H. (1991)
8-chloroadenosine-3',5'-monophosphate inhibits the growth of Chinese hamster ovary and molt-4 cells through its adenosine metabolite.
Cancer Res. 51, 1600 - 1605

97 Cho-Chung, Y.-S., Kessin, R.H., Villalba Diaz, F., vanLookeren-Campagne, M.M., and Jastorff, B. (1991)
Correspondence re: Michiel van Lookeren-Campagne et al., 8-Chloroadenosine 3',5'-monophosphate inhibits the growth of Chinese hamster ovary and molt-4 Cells through its adenosine metabolite.
Cancer Res. 51, 6206 - 6208

98 Døskeland, S.O., Boe, R., Bruland, T., Wintermyr, O.K., Jastorff, B., and Lanotte, M. (1991)
Criteria used to judge that a cellular response is mediated by cAMP.
In: Methodological Surveys in Biochemistry and Analysis (E. Reid, senior editor), 21, 103 - 114

104 Naß, N., Colling, C., Cramer, M., Genieser, H.-G., Butt, E., Winkler, E., Jaenicke, L., and Jastorff, B. (1992)
Mapping of epitope/paratope interactions of a monoclonal antibody directed against adenosine 3',5'-monophosphate.
Biochem. J. 285, 129 - 136

105 Jastorff, B., Maronde, E., van Bemmelen, M.X.P., Zorn, M., and Störmann,R. (1992)
Review: Cyclic nucleotide metabolism as a target in chemotherapy.
Molecular Aspects (1992) of Chemotherapy 3rd. Int. Symp. 1991,
Ed. Shugar, D., Rode, W., Borowski, E., p. 73 - 104, Polish Scientific Publishers, Warszawa, Springer

109 Monsees, T., Meijer, L., and Jastorff, B. (1993)
8-Dimethylamino-1-methyladenine, a novel potent antagonist of the 1-methyladenine receptor in starfish oocytes.
Eur. J. Biochem. 2/3, 155-165, FEBS (1993)

110 Zorn, M., Maronde, E., Jastorff, B., and Richter-Landsberg, C. (1993)
Differential effects of two structurally related N6-substituted cAMP analogues on C6 glioma cells.
Eur. J. Cellbiol. 60, 351 - 357

111 Van der Meulen, R.M., Heidekamp, F., Jastorff, B., Horgan, R., and Wang, M. (1993)
Effects of abscisic Acid analogues on abscisic acid induced gene expression in Barley aleurone protoplasts: Relationship between structure and function of the abscisic acid molecule.
J. Plant Growth Regul. 12, 13 - 19

112 Soede, Ron D.M., Peters, Dorien J.M., Jastorff, Bernd, Van Haastert, Peter J.M., and Schaap, Pauline (1993)
A pharmacological approach to identify hormone signalling pathways controlling gene regulation in Dictyostelium. New developments in lipid-protein interactions and receptor function.
NATO ASI Series, Serie A: Life Science 246, 87 - 101 (ed. K.W.A. Wirtz, L. Parker, J.A. Gustafsson, A.E. Evangelopoulos, and J.P. Changeux), Plenum Press, New York

120 Feldwisch, O., Lammertz, M., Hartmann, E., Feldwisch, J., Palme,K., Jastorff,B., and Jaenicke,L. (1995)
Purification and characterization of cAMP-binding protein of Volvox carteri f. nagariensis Iyengar.
Eur. J. Biochem. 228, 480 - 489

126 Skladanowski, A.C., Hoffmann, C., Krass, J., Jastorff, B., and Makarewicz, W. (1996)
Structure-activity relationship of cytoplasmic 5'-nucleotidase substrate sites.
Biochem. J., 314, 1001 - 1007

123 Ruchaud, S., Zorn, M., Davilar-Villar, E., Genieser, H.-G., Hoffmann, C., Gjersten, B.T., Døskeland, S.O., Jastorff, B., and Lanotte, M. (1995)
Evidence for several pathways of biological response to hydrolysable cAMP-analogs using a model system of apoptosis in IPC-81 leukemia cells.
Cell. Pharmacol. 2, 127 - 140

131 Hoffmann, C., Raffel, S., Ruchaud, S., Gendron, M-C., Kruppa, J., Zorn, M., Døskeland, SO., Lanotte, M., and Jastorff, B. (1996)
Chloro-substituted cAMP analogues and their adenosine metabolites induce apoptosis of the human promyeloctic leukaemia cell line NB4: molecular basis for cell type selectivity.
Cell.Pharmacol. 3, 417 - 427

140 Kozlowska, M., Smolenski, R.T., Makarewicz, W., Hoffmann, C., Jastorff, B., and Swierczynski, J. (1999)
ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside.
Toxicology Letters 104, 171 - 178

Umweltforschung

38 Jastorff, B., Leo, R., Gerschler, L.J., Leo, D., und Nill, B. (1982)
Verwertung von ölhaltigen Abfallstoffen der ölbohrenden und -verarbeitenden Industrie Mexikos aus ökonomischer und ökologischer Sicht.
BMFT-Forschungsbericht

39 Jastorff, B., Leo, R., Leo, D., Nill, B., und Wunderlich, G. (1982)
Aufnahme und Beseitigung von Ölschlämmen aus Förder-, Transport-, und Löschunfällen im Watt-Strand-Bereich der Deutschen Küste.
BMFT-Forschungsbericht

53 Blohm, M., Braun, H., Kaschny, P., Schill, H., Jastorff, B., and Diehl, H. (1985)
Subacute toxicity of 1,1,1-trichloroethane, noise, and their combination in rats.
Ecotoxicol. Environ. Safety 10, 295 - 301

69 Diehl, H., Braun, H., Kaschny, P., Schill, W., Störmann, R., and Jastorff, B. (1987)
The concept and application of an experimental differential combination method. Recent advances in researches on the combined effects of environmental factors
(Eds. Okada, A., and Manninen, O.), Kyoei Co. Ltd. Kanazawa, Japan, 654 - 677

77 Diehl, H., Oelkers, B., Kaschny, P., Braun, H., Störmann, R., Schill, W., and Jastorff, B. (1988)
Effects from inhalation of combined organic solvents.
O. Recent Adv. in Res. on the Combined Effect of Environmental Factors 501 - 514, Tampere

83 Diehl, H., Braun, H., Kaschnny, P., Oelkers, B., Schill, W., Störmann, R., und Jastorff, B. (1989)
Modelluntersuchung zur kombinierten Einwirkung von Lösungsmitteldämpfen bei unterschiedlich komplexer Zusammensetzung.
Studie im Auftrag des Bundesministers f. Forschung u. Technologie, Kennzeichen 01VD023

100 Störmann, R., und Jastorff, B. (1991)
Alle Dinge sind Gift... Lassen sich die Wirkungen von Umweltchemikalien prognostizieren?
Impulse aus der Forschung 11, 5 - 13, Universität Bremen

113 Störmann, R., and Jastorff, B. (1993)
Ecological risk assessment and the regulation of chemicals I. Exposure and hazard identification of metabolites.
The Science of the Total Environment, Suppl., 1657 - 1667

142 Köhler, M., Jastorff, B., Weis, N., Stolz, P. (1998)
Sind Prüfkammeruntersuchungen praxisgerecht ? Einfluss von Beladung und Luftwechsel
AGÖF-Fachkongress 98, 270 - 274

144 Hoffmann, I., Warrelmann, J., Jastorff, B., Schultz-Berendt, V., Werner, P. (1999)
Reinigung sprengstoffbelasteter Wässer durch ein chemisches Reduktionsverfahren.
TetraTech 2, 49 - 51

147 Ranke, J., Jastorff, B. (2000)
Multidimensional risk analysis of antifouling biocides.
Environ. Sci. Poll. Res. 7 (2), 105 - 114

152 Koehler, H., Frische, T., Dobner, I., Behrend, P., Schaefer, M., Taubner, H., Warrelmann, J., Walter, U., und Jastorff, B. (2001)
Erprobung und Erfolgskontrolle eines Phytoremediationsverfahrens zur Sanierung Sprengstoff-kontaminierter Böden. Teil II: Ergebnisse eines Freilandexperiment
UWSF - Z. Umweltchem. Ökotox. 13, 1 - 10

153 Stepnowski, P., Blotevogel, K.-H., Ganczarek, P., Fischer, U., und Jastorff, B. (2001)
Total recycling of chromatographic solvents - applied management of methanol and acetonitrile waste.
Resources, Conservation and Recycling (in press)

154 Koehler, H., Warrelmann, J., Behrend, P., Frische, T., Dobner, I., Walter, U., Heyser, W. und Jastorff, B. (2001)
Erprobung und Erfolgskontrolle eines Phytoremediationsverfahrens zur Sanierung Sprengstoff-kontaminierter Böden. Teil III: Beurteilung des Verfahrens.
UWSF - Z. Umweltchem. Ökotox. 13, 359 - 368

156 Brandsch, R., Nowak, K.-E., Binder, N. und Jastorff, B. (2001)
Investigations Concerning the Sustainability of Remediation by Land Deposition of Tributyltin Contaminated Harbour Sediments.
J. Soils & Sediments 1 (4), 199 - 264